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KMID : 0376219950310010141
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Chonnam Medical Journal
1995 Volume.31 No. 1 p.141 ~ p.150
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Antipsychotic drug-induced menstrual disorder in schizophrenic women
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Abstract
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The purpose of this study was to see the morbidity of menstrual distubance after antipsychotic medication in schizophrenic women, and to compare the characteristics of drugs between regular and irregular menstrual groups.
the subjects of the study were composed of 75 female patients who were admitted to psychiatric wards in Kwang-ju and Chonnam area. They were not medicated at least one month prior to admission, and had a normal menstrual interval(i.e from 24 to
32
days). We evaluated retrospectively at the point of three months after admission to see menstrual disturbance for those who have had no menstruation untl 5-6 weeks after medication.
Medication status means dosage and the sort of drugs.
The result was shown as follows: 1) lrregular menstruaton occurred to 39 of 75patients952%). They had irregular menstruation within two months after medication (94.88%). 2) Total patients' distribution according to drug potency was shown a
significant
difference both in irregular and regular groups(p<0.05). The patients who medicated on high potent drugs have shown no difference between two groups, but the irregular group seemed to respond to intermediate potent drugs and normal group to low
potent
drugs. 3) There was a significant difference in Chlorpromazine equivalent avergae dose between irregular and regular group(P<0.0001) for three months after medication, and it also showed significant difference between two groups on high potent
drugs(P<0.0001).
The above results suggest that morbidity of menstrual disturbance is high in schizophrenic female patients in a short time who were medicated antipsychotic drugs and who were medicated on high dosage.
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KEYWORD
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